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As glutathione can improve the numbers and activity of macrophages, peptic ulcers may be exacerbated [40] Increased susceptibility to melanoma: Theoretically, long-term administration of systemic glutathione switches eumelanin to pheomelanin, and may increase the susceptibility towards development of melanoma in the long run

Natural antioxidants from some fruits, seeds, foods, natural products, and associated health benefits: an update

Recently a novel covalent inhibitor EN25 and its derivatives targeting GCLM subunit were discovered through covalent library screening, with a reported IC 50 of 16 M in 15 min reaction for EN25 and 6.8 M for the most potent derivative EN258 [71]