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However, there is insufficient evidence indicating that holistic management of glycemia and other risk factors can alleviate the neuropathic pain

Confusingly enough, cuprizone also does not kill oligodendrocytes in vitro [111], suggesting that cuprizone alone might not be enough to induce oligodendrocyte cell death in vivo

Have severe or unstable medical conditions (e.g., uncontrolled diabetes, end-stage renal disease, significant heart or liver disease) without first consulting a physician

The expression levels of Kim-1 and NGAL were increased 4 to 5-fold in the kidneys, resulting in significant nephrotoxicity