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The intranasal administration method has several advantages, including non-invasiveness, ease of self-administration, the ability to directly cross the BBB, rapid onset of action, and avoidance of the first-pass metabolism effect in the liver, thus improving the bioavailability of the drug

The synthesis of Ru-hydroxide was achieved by dispersing and stirring 50 mg of the as-prepared hydroxide in 50 mL aqueous RuCl 3 xH 2 O (10 mg) solution under ambient conditions for 24 h

doi: 10.1042/BJ20091087 [DOI] [PMC free article] [PubMed] [Google Scholar] 171

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