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2.2 Metabolism and signaling of endogenous RSS 2.2.1 H 2 S generation: tissue-specific enzyme distribution and regulatory properties Intracellular H 2 S generation primarily depends on three enzymes ( 2+ -responsive regulation via calmodulin, enabling rapid H 2 S generation during immune activation ( 2 S source ( 2.2.2 Mitochondrial H 2 S oxidation: closing the metabolic loop H 2 S oxidative metabolism represents a critical regulatory axis controlling cellular RSS levels