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581,582 It has undergone several clinical trials for various conditions, including Menieres disease (Phase III, NCT04677972), bipolar disorder, complete middle cerebral artery occlusion, delayed neurological deficits following aneurysmal subarachnoid hemorrhage, and acute ischemic stroke

218 LTB4 activates the BLT1 receptor on VSMC and induces VSMC activation and proliferation through an IKK-NF B-dependent pathway, which is important in early atherosclerotic formation