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This process subsequently cleaves the effector caspases-3 and -7, triggering terminal apoptotic events such as DNA fragmentation and nuclear membrane dissolution ( 2.4.2 Endoplasmic reticulum pathway Endoplasmic reticulum (ER)-mediated apoptosis represents a crucial regulatory pathway of programmed cell death

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6 Systemic manifestations Systemic manifestations are common and include flulike symptoms, fever, lymphadenopathy, and mucosal involvement (conjunctival, oropharyngeal, esophageal, and genital)