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In macrophages infected with Leishmania donovani , activation of PINK1/Parkin-mediated mitophagy reduces mtROS accumulation and prevents uncontrolled inflammasome activation ( 5.5 Parasite-induced mitochondrial signaling and immune evasion Mitochondria orchestrate several innate immune pathways critical for parasite control, including NLRP3 inflammasome activation and type I interferon responses

Despite its critical function, the development of effective and selective inhibitors targeting SLC1A5_var has remained a significant challenge

Colonna, M

Acknowledgements We thank the Centro Piattaforme Tecnologiche of the University of Verona for providing access to the CD spectropolarimeter