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s = broad singlet, d = doublet, t = triplet, q = quartet, dd = doublet of doublet and m = multiplet

Although CHKs did not show differential expression at 24 hours post-treatment, it is plausible that such changes may manifest at later timepoints subsequent to RRM2 downregulation

Meanwhile, a complex feedback system can regulate GH secretion, including IGF-1, leptin, and ghrelin along with the central nervous system

These studies benefit from large sample sizes and long-term follow-up but are inherently limited by confounding factors (e.g., overall diet quality, lifestyle variables) and the inability to establish causality ( Conversely, randomized controlled trials (RCTs), while methodologically superior in reducing bias, have yielded more inconsistent results