foxo4 dri senolytic or senomorphic Development of a novel by precise disruption of FOXO4-p53 complex CHK2-USP37 axis stabilizes FOXO4 to

CHK2 USP37 axis stabilizes FOXO4 to sustain senescence and evade apoptosis PNAS The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity. Senolytics: charting a new course or enhancing existing anti tumor therapies? Cellular Oncology Springer Nature Link Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment npj Aging

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