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Di Martino V, Verhoeven DW, Verhoeven F, Aubin F, Avouac J, Vuitton L, Liote F, Thevenot T, Wendling D (2023) Busting the myth of methotrexate chronic hepatotoxicity

Greenwood were supported by funds from the Leibniz Gemeinschaft, SAW-2015-IZW-1 440

Activation of alpha-1 leads to the (i) contraction of the iris dilator and Mullers muscles, leading to mydriasis and lid retraction, (ii) vasoconstriction causing the restriction of blood flow to the ciliary muscle, and (iii) reduced aqueous humor production [215]