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And a head-to-head comparison of 0.05% retinal against a 0.05% retinoid acid found both formulations were effective for the basis of wrinkle/skin roughness features, but retinoic acid caused more local irritation

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TLR9 antagonists, such as synthetic oligodeoxynucleotide antagonists (e.g., IRS-954) and chloroquine, inhibit TLR9 activation and downstream NF-B signaling, reducing pro-inflammatory cytokine release from microglia and astrocytes [197]