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Interestingly, selective inhibition of VDAC1 oligomerization by VBIT-4 significantly attenuated the LPS/IFN--induced increase in mtROS levels (Fig

Sirtuins are a family of NAD + -dependent deacylases that have been shown to regulate a myriad of biological functions, ranging from cell growth to lifespan extension, including oxidative stress, DNA damage, glycolysis, gluconeogenesis, and lipogenesis [1316]