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Melasma is an acquired hypermelanosis that appears mainly on sun-exposed areas, especially the face, and may be associated with pregnancy or oral contraceptives

In terms of bioproduction, these variations can create a wide range of metabolite- and protein-of-interest levels among individual cells within producing populations

Based on the amount of information known about the actions of CBD, we hypothesize the anti-inflammatory effects are likely to be the most promising therapeutic mechanism

Emerging evidence posits that targeted nutritional interventionsencompassing fat-soluble vitamins (D, E, K), water-soluble vitamins (B8, B9, B12), essential minerals (zinc, selenium, chromium, calcium, magnesium), and bioactive compounds (melatonin, -3 PUFAs, CoQ10, NAC)may mitigate core PCOS manifestations including IR, dyslipidemia, HA, and chronic inflammation (Table 1)