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There is still a gap in existing research in the field, necessitating well-designed, robust, multicenter clinical trials, with sensitive endpoints and standardized protocols to facilitate the diagnosis of DPN via a simple and effective algorithm and to track progression of disease and treatment response

First, to give readers a clear overview of the mechanism of action of nanocarriers used in active and passive targeting, we briefly describe how they interact with bacterial membranes and how the drug is released to exert its effect

The down-regulation of the p53 gene protects hair cells from Bcl2 family translocation, cytochrome c translocation, caspase3 activation, and ultimately cell death, as it operates upstream of the mitochondrial apoptotic pathway