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Mast Cell Activation Syndrome (MCAS) is a disease of the connective tissue, nervous system, and lymphatic system

Our in-depth analysis reveals that during the hyperinflammatory phase, the stabilization of HIF-1 and the activation of mTOR drive the metabolic shift towards glycolysis, promoting the cytokine storm

Therefore, diabetic metabolic dysregulation critically subverts pulmonary immune resilience by destabilizing surfactant integrity, amplifying infection susceptibility through combined biosynthetic, antimicrobial, and lipidome perturbations

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