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Research on ferroptosis began with the discovery of the small-molecule erastin

Int J Mol Sci 21:8767

Similarly, NACs antioxidant action and ability to modulate kinin B1 receptor expression may alleviate sensory polyneuropathy, hypertension and metabolic parameters associated with diabetes and insulin resistance, as diabetes mellitus is associated with depletion of cellular antioxidants and an increase in reactive oxygen species levels with resultant protein damage [14]