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The fact that methylation clocks trained on chronological age alone (with no input concerning mortality or disease state) turn out to be better predictors of life expectancy than age alone is a powerful validation of methylation technology

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Triptolide can inhibit LPS-induced FLSs migration and invasion by inhibiting TLR4/NF-kB pathway-mediated MMP-9 expression (96), and the molecular mechanism for inhibition of MMP-9 is to inhibit MMP-9 transcriptional activity by inhibiting NF-kB binding activity in the MMP-9 promoter