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Representative mutations are those that interfere with contact points between the and subunits (e.g., Hb Philly [ 35TyrPhe ]), alter the helical segments (e.g., Hb Genova [ 28LeuPro ]), or disrupt interactions of the hydrophobic pockets of the globin subunits with heme (e.g., Hb Kln [ 98ValMet ]) (Table 127-3)