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234 Immunosenescence promotes the development of AMD by causing low-grade chronic inflammation in the retina and choroid

Starting at the left SARS-CoV-2 binds to the ACE2 receptors on cell membranes, decreasing ACE2 activity That cause an increase in Angiotensin 2 and a decrease in Angiotensin 1 and 7 That increases Hydroxy Radical (OH ) That causes endothelial cell dysfunction (affecting the cells lining the blood vessels) That triggers an increase in Von Willebrands Factor (vWF), released when there is damage to the endothelium Which then causes thrombosis (clotting) Recent autopsies of lungs from people that have died of COVID-19 have found that the small vessels are full of these clots, reducing blood flow and preventing oxygenation of the blood

10.2147/JIR.S420676 117 WeiX.YiX.ZhuX.-H.JiangD.-S

doi: 10.1038/oncsis.2014.18 52 Audet-WalshEDufourCRYeeTZouanatFZYanMKalloghlianGet al