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Furthermore, ribosomal protein S6 kinase alpha-3 (RSKs) down-regulates the expression of ERK signaling and mediates the regulation of mitogenic and stress-induced phosphorylation that causes unintentional growth, and mediates cellular proliferation, survival, and distinction by tempering mTOR signaling and suppressing the pro-apoptotic role of BAD and DAPK1 [55,56]