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Among the specific anticoagulants discovered are the kininogen cleaving serine protease Sk1, the - and -thrombin binding/inhibiting membrane bound antigen Sm 22.6, the ATP-diphosphohydrolase enzyme Sm ATPDase1 that cleaves the platelet activator ADP, the more recently characterized tegumental calpains S, Calp1 and Sm Calp2 that cleave host fibrinogen, and finally, the secreted serine protease Sm SP2 that activates parts of the fibrinolytic system and promotes vasodilation (162165)