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doi: 10.1016/j.toxicon.2010.03.010 66 SenthilkumaranSDavidSSMenezesRGThirumalaikolundusubramanianP

Limitations of traditional mechanistic frameworks Traditional models of CVD-cognitive impairment comorbidity primarily focus on vascular-mediated processes, including cerebral hypoperfusion, where arterial stenosis or HF-induced reduction in blood flow impairs the delivery of oxygen and nutrients to neurons