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Other symptoms are severe jaundice, diarrhoea, fever, pruritus, and hepatosplenomegaly

[52] In light of the disappointing results of clinical trials involving the administration of so-called direct antioxidants (e.g., vitamins C or E or beta carotene) [37], there is growing interest in strategies based on dietary or pharmacological upregulation of endogenous antioxidant defense genes, including those regulated by the master antioxidant and cell protective transcription factor nuclear factor (erythroid-derived 2)-like-2 (Nrf2), which regulates hundreds of antioxidant and cytoprotective proteins [20] by binding at antioxidant response element (ARE) consensus sequences in the promoter region of those genes

Comprehensive Profiling of Diverse Genetic Reporters with Application to Whole-Cell and Cell-Free Biosensors

Morphine has a high intrinsic hepatic clearance and about 60% of morphine is removed by first pass extraction after an oral dose