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(2021d)

Anti-tumor efficacy in vivo The tumor-bearing mice were randomly divided into six groups (5 mice in each group) as follows: (1) Control (200 L of saline injection), (2) Bi 2 S 3 (Bi: 5 mg mL 1 , 200 L), (3) Bi 2 S 3 -3BP (Bi: 5 mg mL 1 ,3BP: 0.8 mg mL 1 , 200 L), (4) X-ray, (5) Bi 2 S 3 (Bi: 5 mg mL 1 , 200 L) + X-ray and (6) Bi 2 S 3 -3BP (Bi: 5 mg mL 1 ,3BP: 0.8 mg mL 1 , 200 L) + X-ray

Distinct from the livers traditional first-pass effect, the stroma actively integrates nutrient availability with the metabolic demands of cancer cells 24,25

Spadaro O, Camell CD, Bosurgi L, Nguyen KY, Youm Y-H, Rothlin CV, et al