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[79] showed that glutamine uptake is blocked in lymphocytes when ERK was inhibited, thus demonstrating that in these cells, ERK is a central player in cellular metabolic control

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The produced H 2 O 2 was then converted into O 2 by virtue of the CAT-like activity of the ACPP to relieve the hypoxic TME and compensate for the consumption of O 2 in the GOD-like catalysis process, thus resulting in the cyclic consumption of glucose and the self-supply of H 2 O 2 substrates used to generate OH