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Mitochondria and ferroptosis in the testis Mitochondria are the powerhouses and the sources of ROS production in eukaryotic cells [50]

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Hence, the presence of iron overload in the FF of infertile patients with EMs can promote NCOA4 expression within granulosa cells, leading to active ferritinophagy, which further contributes to the development of ferroptosis by enhancing lipid peroxidation in granulosa cells