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The challenge for ICU physicians caring for TBI patients would be to detect the stage of the disease via the implementation of biomarkers or imaging and thus be able to apply personalized medicine to improve outcomes

[DOI] [PMC free article] [PubMed] [Google Scholar] 374.Yan C., Wang T

SIRT3 overexpression in HSCs improves the function of distant tissues through myeloid cells Adoptive transfer experiments demonstrated that splenocytes from aged mice were sufficient to induce systemic senescence in young recipients, despite the short-lived nature of donor immune cells, supporting the concept that relatively small numbers of functionally altered immune cells can exert broad physiological effects through systemic signaling mechanisms, without requiring long-term engraftment 52

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