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Given its proximity to helices 10 and 11 of the HECT N-lobe and to the binding interface between the HECT and C2 domains, the catalytic residue C922 cannot be accessed in Nedd4-2 (Fig

On the other hand, cellular GPx activity level showed a positive correlation with quasi-threshold doses (Dq) and extrapolation numbers but not with general radiosensitivity

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Vascular Endothelial Growth Factor (VEGF), as disclosed in International Publication Number WO 90/13649