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By preserving SAM, NNMT inhibition may restore normal epigenetic control of metabolic gene expression in fat cells

While these 2 trials have generated considerable optimism about a future role of GLP1 agonists as disease-modifying both in the PD research and patient community, a recent placebo controlled phase 3 trial of exenatide in 215 subjects with early PD on symptomatic therapy failed to meet its primary endpoint and found no significant difference in MDS-UPDRS part III OFF-scores at 96 weeks [187]

Tirzepatide with Methylcobalamin (Methylated B12) Methylcobalamin is the bioactive form of Vitamin B12