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Med Sci Monit 2017, 23: 15971606

However, long-term use of very high doses (exceeding 5 mg per day) may pose certain risks, such as masking the early hematological signs of vitamin B12 deficiency, thereby potentially delaying the diagnosis of its neurological complications (69)

EBioMedicine 60, 102999

ML226 treatment resulted in HIF-1 stabilization, upregulation of HIF-1 target genes ( CAIX and VEGF ), and activation of a HIF-1 fluorescent reporter (HRE-GFP ODD ) in HeLa cells, similar to treatment with cell-permeable (DM-2OG