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Unlike ulcerative colitis, which is limited to the colonic mucosa, Crohns disease features skip lesions areas of diseased bowel separated by segments of normal-appearing tissue and may involve multiple layers of the intestinal wall, leading to fibrosis, stricture formation, and fistulization, as described by the Crohns & Colitis Foundation

and disrupting BBB integrity by activating Toll-like receptor signaling pathways, remodeling the cytoskeleton, and damaging brain microvascular endothelial cells

In Alzheimers disease nanomedicine, LLCNPs may therefore be useful for delivering poorly soluble neuroprotective agents, anti-inflammatory compounds, peptides, or gene-modulating cargos

If approved, they prescribe the appropriate medication and dosing plan