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Reagents and relative costs for different types of affinity chromatography

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The former mechanism is preferred because RS scavengers can be consumed during the reaction and may generate toxic radicals derived from the chelators ( One of the first chelating agents documented to reduce RS production (specifically the hydroxyl radical) in vitro was diethylenetriaminepentaacetic acid (DTPA)

Peripheral administration and AAV-mediated liver expression of brain-penetrant PGRN biologics have been shown to rescue phenotypes of Grn / mice and Grn / Tmem106b / DKO mice, respectively [197, 210]