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For instance, during chemotherapy or targeted therapy, surviving DTPs exhibit epigenetic changes characterized by increased methylation of histone H3 at lysine sites (such as H3K27 and H3K9) and dynamic remodeling of the open chromatin architecture to maintain plasticity [162, 163]

The explanation of this phenomenon could be the progressive decline in the efficacy of BTX-A, which coincides with the loss of the window of opportunity that enables the fullest possible rehabilitation

MDA is a relatively stable oxidizing molecule that shows similar cytotoxicity and mutagenic potential with 4-HNE, reacting with various proteins and biomolecules

An article on his funeral was featured on September 21, 1894, in the New York Tribune