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Palaniappan K, Lin YET, Vogel S

However, Bacteroides and Bifidobacterium are also enriched in the CVD state, which may be attributed to the fact that CVD puts the organism in a state of stress, leading the immune system to produce compensatory mechanisms to participate in the regulation of intestinal immune homeostasis, enhance the intestinal barrier function, prevent excessive invasion of pathogenic bacteria, and counteract the disturbance of the internal environment caused by CVD

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This randomized, placebo-controlled, multiple-ascending dose, phase 1b trial aims to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics increasing cagrilintide doses (0.16 4.5 mg) vs