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Because cortisol competes with progesterone for the same receptor sites and steals from the pregnenolone pool that feeds sex hormone production, women with high cortisol frequently experience irregular or absent periods, worsening PMS, low libido, and accelerated symptoms of perimenopause

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Furthermore, iron overload can promote the production of ROS in T cells, which leads to DNA damage and undermines the responsive ability of T cells, thus expediting the pathological process of inflammation (119)

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