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In 28-month-old mice, roughly equivalent to elderly humans, three weeks of GHK-Cu administration produced significantly faster maze navigation with evidence of decreased brain inflammation and increased histone deacetylase 2 labeling, an indicator of epigenetic pathway activation

Rapid reduction or abrupt discontinuation has also been associated with attempts to find other sources of opioid analgesics, which may be confused with drug-seeking for abuse

Quantitative data were obtained using ImageJ software