gastric bypass and b12 injections It sucks when you eat “right” but still end up with an iron deficiency. Or what about being a patient needing vitamin shots for the rest of your Why Vitamin B12 is Important

Prep Your Supplies: Wash hands and gather the B12 cyanocobalamin vial, insulin syringe, alcohol swabs, and a sharps container

Molecular Metabolism 45:101165

Mechanism of Action and Target Biology NNMT Enzyme and Function: Nicotinamide N-methyltransferase (NNMT) catalyzes the SAM-dependent methylation of nicotinamide: Reaction: Nicotinamide + SAM 1-methylnicotinamide (1-MNA) + S-adenosylhomocysteine (SAH) Expression: Liver, adipose tissue (particularly visceral), smooth muscle, some neurons Regulation: Increased expression in obesity, diabetes, aging, certain cancers Substrates consumed: Nicotinamide (NAD+ precursor) and SAM (methyl donor) 5-Amino-1MQ Inhibition Mechanism: Competitive inhibitor with respect to nicotinamide substrate IC: Submicromolar range for NNMT enzyme Selectivity: Minimal inhibition of other methyltransferases at relevant concentrations Result: Increased intracellular nicotinamide availability for NAD+ salvage pathway Downstream Effects of NNMT Inhibition: 1

Relive Hendersonvilles use of AOD9604 also reflects its broader mission to deliver results-driven care