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While some actives may cause mild, brief tingling initially, persistent burning suggests ingredient conflict or over-concentration

Figure 4 Elevated levels of proinflammatory cytokines (e.g., IL-1, IL-6, IL-23, IL-33, TNF, and IL-17) and reduced levels of anti-inflammatory cytokines (such as IL-10, IL-27, and TGF) are commonly termed cytokine dysregulation

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