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Prog Lipid Res 42(4):318343

The Complex Integration of T-cell Metabolism and Immunotherapy

Nat Rev Mol Cell Biol (2018) 19(3):15874

The modification involves replacing the glutamic acid at position 3 with arginine (R3) , and extending the N-terminal region by 13 additional amino acids (MFPAMPLLSLFVN), resulting in a longer peptide chain of 83 amino acids compared to the native 70 in human IGF-1