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While our mechanistic data and mouse model results are compelling, a formal statistical causal inference or randomized controlled design would be required to definitively attribute hyperprogression to the immunotherapy regimen

From there it reaches the cytosol via VDAC [15,121] or it is dismutated by IMS-located SOD1 to H 2 O 2 , which reaches the cytosol via diffusion or aquaporins [85,122,123,124,125,126]

Mononuclear MDSCs (M-MDSCs) have been shown to be implicated in resisting immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1) and are associated with receptor tyrosine kinase (KIT) signaling in CRC (100)

Currently, deferiprone (DFP), a compound that alleviates symptoms related to PD pathology (Gutbier et al., 2020), is evaluated a in phase 2 randomized placebo-controlled clinical trial with AD patients (NCT03234686)