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However, the extracellular concentration of this oxidant is difficult to predict, as it does not only depend on the amount of neutrophils in the inflammatory region, but also on the levels of MPO released during neutrophil activation and availability of H 2 O 2

Moreover, p-JUN inhibitor (p-JUNi) treatment could also rescue CXCL10-induced COL1A1 upregulation, which further validates the downstream fibrosis pathway (Supplementary Fig