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These radicals are highly reactive and capable of attacking cellular lipids, proteins, and DNA, causing severe structural damage and ultimately leading to cell death ( 2.2 Lipid peroxidation system Lipid peroxidation is a central mechanism underlying ferroptosis and plays a critical role in its progression

It has often been suggested that intracellular oxidative stress from hydrogen peroxide or superoxide may result in the oxidation of the cysteine residues of cytoplasmic proteins

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Nakayama, T