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Lipolysis enzymes remodel the M2 lipidome to generate pro-resolving fatty acids To test the hypothesis that HSL activity alters the lipid landscape to support M2 functions, we performed comprehensive lipidomic profiling of M1, M2, and HSL-inhibited M2 (M2 + HSLi) macrophages (Supplementary Tables 12)

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(jofem.org) The best-case signal: modest weight loss in a shorter trial A frequently cited 12-week randomized trial result (as summarized in reviews) reported: ~2.6 kg average loss with AOD-9604 1 mg/day vs ~0.8 kg with placebo (PMC) This is the kind of result that can be statistically meaningful, clinically modest, and very sensitive to study design (diet, activity, baseline metabolic status, adherence)