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Epigenetic Regulation NNMT activity consumes S-adenosylmethionine (SAM), the universal methyl donor required for hundreds of methylation reactions throughout the cell

This strategy outperformed Plaza-Diaz et al.s fecal microbiota transplantation (FMT) protocol, which normalized Firmicutes/Bacteroidota ratios but required repeated invasive procedures and conferred no neural repair [47]

Research on AD models has suggested that reactive astrocytes are more susceptible to neuronal reprogramming than their nonreactive counterparts, underscoring the role of astrocytic heterogeneity in influencing cell differentiation 25,149

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