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Description

More broadly, chronic alcohol exposure reshapes hepatic macrophage populations by promoting the recruitment of bone marrow-derived monocytes, resulting in a mix of resident Kupffer cells and infiltrating macrophages

Notwithstanding this difference, the overall finding of lower GPx activity at 3 weeks of age might imply an over compensation by the elevated CAT activity causing a decrease in the substrate and therefore in GPx activity and its subsequent mRNA expression and perhaps also the higher TAS and unaltered levels of MDA between 2 and 12 weeks