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9 and ESM Tables 1114) Group 1 (newly diagnosed cases) Islets from case 1 were insulin-negative, with strong GPX1 staining in approximately 90% of glucagon cells, while in case 2, 80% of beta cells had weak staining and almost 55% of glucagon cells had moderate to strong staining

doi: 10.1038/s41420-023-01369-2, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 10

Specifically, hepatic insulin resistance leads to the activation of the forkhead transcription factor (FoxO1), which promotes the overexpression of bile cholesterol transport proteins Abcg5 and Abcg8, resulting in excessive cholesterol secretion into bile

This practice limits the ability to confirm whether a specific product batch was independently tested