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Rivaroxaban is contraindicated in those with moderate to severe hepatic impairment, defined as those with Child-Pugh B or C or those with hepatic disease associated with coagulopathy due to the increased risk of bleeding (7)

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Improves circulation and oxygenation of tissues

This activation is accompanied by vital methylation reactions that allow the synthesis of creatine and phosphatidylcholine and the methylation of DNA, RNA, and a large number of neuromediators