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L-Lysine ameliorates diabetic nephropathy in rats with streptozotocin-induced diabetes mellitus

doi: 10.1172/jci131859 252 DouceyMACarraraS

12 The NAD+ salvage pathway is particularly important in cancer cells, as it is the primary method of NAD+ synthesis, and its inhibition has been shown to induce cancer cell cytotoxicity

Epigenetically, it deacetylates H4K16ac, counteracting hMOF activity to promote chromatin condensation and ATG activation (such as ATG7, BECN1 , and LC3B )