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J Nat Prod 69(3):460463 Prostate cancer statistics| World Cancer Research Fund International [Internet] [cited 2023 Jun 27]

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Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)