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It works as a potent antioxidant, improves blood flow to nerves, and enhances glucose uptake all of which can help reduce burning, tingling, and pain associated with neuropathy.1 Clinical trials have shown consistent benefits at 600mg per day, particularly when taken long-term and under medical supervision.7 Benfotiamine (300mg per serving) Benfotiamine is a fat-soluble form of vitamin B1 (thiamine) with significantly better bioavailability than standard thiamine.46 It plays a central role in glucose metabolism and helps prevent the accumulation of harmful byproducts like advanced glycation end products (AGEs), which contribute to nerve damage in diabetes

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The authors concluded that a larger randomized placebo-controlled study is needed before efficacy claims can be made

In this chapter, we adopt a dual framework integrating technology-driven and clinical application-oriented approaches, leveraging a progressive structure that transitions from basic research to clinical implementation, and from molecular mechanisms to intervention strategies